Process of producing derivatives of cantharidic acid containing iodin and mercury.



O m, or BERLIN, G R ANY PROCESS OF PRODUCING DERIVATIVES FOAN'I'H'ARIDIC ACID CONTAINING IODIN AND H RO Y.

i 1,01 7,560 Specification of Letters Patent. Patented Feb, 13, 1912, R0Drawing Application filed June 29, 1811. Serial No. 886,018. Toall w omit no of cant aridin t d 1th alkali, a mix- Be it wn hat I, ALEXA mmKLEIN, ure ercuric hlorid an iodid of so a subject of the peror ofermany, re dium dded and treated in the first sldmg at Berlin, ermany,have invented a exam wher on, according t e 45 5 ne and useful Improvment 'n recesses amount of alka used, either combination for ProducingDerivatives of Cantharldic of he nstitu ts, dissolved n the liquid, cidContaining Iodin and ercury, of which example may be lcohol, is whichthe followlnf is a specification. formed, a non-soluble c is obinventione ates to mprovement tained y mg a greater amount of alkali. 5o in t eprocess f produc' g de vatives of Suitable lvents o e th n 10 h 1 maycantharidic acid containin d nd mere used ury, set forth German Patent,No. The advantage of thi ne proc IS the 193,219, in w ess a precipitateof production at ill of quite soluble, part1 iodln cantharidinate in theform of a solubl non-sol ble unds In a sta- 16 der is formed up the add'on of sod e stat sultite to a ale holic solution of canth or ing theroduet, 0 obtained, as a cacid,mercur 1c c orid, and iodi caustic, ma[is wholly dissoiv d m he present invention has for its ob ect iquid, rapplied as solid p der, or the production of su h derivativ n formsmixed wt a unge t or other 20 of'various solubilities This res t In theces, for

p esent invention is attained by the use alkali; and the gr te thealkali used, th

u ,sub 00 e its exam 1e, alcohoF reform, aldehydes, E amount of thesubstances, etc. c more insoluble p not formed h 26 th ols, oils, fattyis the r portant advan of the produ t best r is to mlx the proc fl es ine 06 e cantharidin with the alkali before aidof ea 11 dividingthe'product into do In the other co tituents. In tead of usm 86s 0gcompounds of iodin, a for example, at I claim is y It f th same, mag ben; or The process of producing a derivative of compounds of iodin may berought d1 t1 cantharidic aci c ining iodin and merin reaction with thmercury. cury consisting in reating a solution of The des d resui ma beobtained in ca tharidic acid with tanoeseconta follow g a s' a. Cantandic acid or tmc- 1n 1 m and mercury in the presence of an ire of naridin 1th a In al 1 amount of alkali is added 0 a mixture in witnesswhereof I have hereunto 1s of one molecule fercurlc ehlorid and signedmy name in presence of two subhalf a molecule i allowed rest scribingwitn sses this 14th day of June or shaken, or boiled, here pon, upondis- 1911. ap ranee of the iodm, a lar ount ALE ANDER KLEIN. amentseparates be ostl non-solu- Witn sses 40 bis, forming a derivative oflow solubil ty o oanthari id in ure

